Quick answer: It depends entirely on your insurance. With covered commercial insurance, both can reach as little as $25/mo. Without coverage, Zepbound self-pay vials (~$349–499) often undercut Wegovy's NovoCare price (~$499).
Cost side by side
| Zepbound (Lilly) | Wegovy (Novo) |
|---|
| With covered insurance + card | from $25 | from $0–25 |
| Self-pay / direct pharmacy | $349–499 | ~$499 |
| TrumpRx.gov | from $299 | varies |
Which is cheaper for you? Four questions
- Does your commercial plan cover one but not the other? The covered one wins — the card makes it ~$25.
- No coverage at all? Compare Zepbound self-pay vials vs Wegovy NovoCare — Zepbound vials often edge it.
- On Medicare/Medicaid? Neither card applies; compare self-pay programs only.
- Supply issues locally? Availability can decide it as much as price.
Beyond price
Zepbound (tirzepatide) and Wegovy (semaglutide) are different molecules with different dosing and clinical profiles. Cost is only one factor — your prescriber should guide the medical choice. This guide covers price, not which drug is right for you.
Frequently asked questions
Is Zepbound or Wegovy cheaper?+
With covered commercial insurance, both can reach as little as $25/month via their savings cards. Without coverage, Zepbound self-pay vials (about $349–499) often undercut Wegovy's ~$499 NovoCare price.
Can I use a savings card for both?+
Each has its own manufacturer card — Lilly for Zepbound, Novo Nordisk for Wegovy — and both generally require commercial insurance. Government insurance is excluded from both.